Around 8:40 p.m., Toronto police said they were responding to reports of shots fired in the area of Danforth Road and Main Street.
Officers responded and found a man suffering from gunshot wounds.
He was then taken to hospital by Toronto Paramedics, police said.
So far there is no information on possible suspects.
Roads have been closed in the area as officers investigate the shooting.
Police are asking anyone with information to contact investigators.
The shooting marks at least the third incident of gun violence in the city this weekend following two shootings hours apart in the Entertainment District Saturday night and overnight.
One shooting just outside the Scotiabank Arena left a male victim dead, while the other at a club on King Street West seriously injured a man and woman in their 20s.
